Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)
TISSUE(S): Heart
DISEASE(S): Laron Syndrome
SUBMITTER: Thomas Fröhlich
LAB HEAD: Thomas Fröhlich
PROVIDER: PXD019852 | Pride | 2020-12-01
REPOSITORIES: Pride
Hinrichs Arne A Riedel Evamaria O EO Klymiuk Nikolai N Blutke Andreas A Kemter Elisabeth E Längin Matthias M Dahlhoff Maik M Keßler Barbara B Kurome Mayuko M Zakhartchenko Valeri V Jemiller Eva-Maria EM Ayares David D Bidlingmaier Martin M Flenkenthaler Florian F Hrabĕ de Angelis Martin M Arnold Georg J GJ Reichart Bruno B Fröhlich Thomas T Wolf Eckhard E
Xenotransplantation 20201125 2
<h4>Background</h4>Many genetically multi-modified donor lines for xenotransplantation have a background of domestic pigs with rapid body and organ growth. The intrinsic growth potential of porcine xeno-organs may impair their long-term function after orthotopic transplantation in non-human primate models. Since growth hormone is a major stimulator of postnatal growth, we deleted its receptor (GHR-KO) to reduce the size of donor pigs in one step.<h4>Methods</h4>Heart weight and proteome profile ...[more]