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N-terminal acetylation by NatB in Arabidopsis thaliana

ABSTRACT: N-terminal acetylation (NTA) is one of the most abundant protein modifications in eukaryotes and is catalysed in humans by seven N-acetyltransferases. In this study, we investigated the Arabidopsis thaliana NatB catalytic (NAA20) and auxiliary subunit (NAA25) and their influence on protein N-terminal acetylation using the SILProNAQ approach

OTHER RELATED OMICS DATASETS IN: GSE132978

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress)

TISSUE(S): Leaf

SUBMITTER: Willy Bienvenut

LAB HEAD: Willy Vincent Bienvenut

PROVIDER: PXD016209 | Pride | 2019-11-21

REPOSITORIES: Pride

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NatB-Mediated N-Terminal Acetylation Affects Growth and Biotic Stress Responses.

Huber Monika M Bienvenut Willy V WV Linster Eric E Stephan Iwona I Armbruster Laura L Sticht Carsten C Layer Dominik D Lapouge Karine K Meinnel Thierry T Sinning Irmgard I Giglione Carmela C Hell Ruediger R Wirtz Markus M

Plant physiology 20191119 2

N<sup>∝</sup>-terminal acetylation (NTA) is one of the most abundant protein modifications in eukaryotes. In humans, NTA is catalyzed by seven N<sup>α</sup>-acetyltransferases (NatA-F and NatH). Remarkably, the plant Nat machinery and its biological relevance remain poorly understood, although NTA has gained recognition as a key regulator of crucial processes such as protein turnover, protein-protein interaction, and protein targeting. In this study, we combined in vitro assays, reverse genetics ...[more]

PMID: 31744933

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