Ontology highlight
ABSTRACT:
DISEASE(S): Diabetes Mellitus,Normal
SUBMITTER: Junmin Liu
Ronald Kahn
PROVIDER: E-CBIL-20 | ArrayExpress | 2009-07-28
REPOSITORIES: ArrayExpress
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E-CBIL-20.2columns.txt | Txt | |||
E-CBIL-20.2columns.xls | Xls | |||
E-CBIL-20.README.txt | Txt | |||
E-CBIL-20.biosamples.map | Other | |||
E-CBIL-20.biosamples.png | Other |
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Gunton Jenny E JE Kulkarni Rohit N RN Yim SunHee S Okada Terumasa T Hawthorne Wayne J WJ Tseng Yu-Hua YH Roberson Russell S RS Ricordi Camillo C O'Connell Philip J PJ Gonzalez Frank J FJ Kahn C Ronald CR
Cell 20050801 3
beta cell dysfunction is a central component of the pathogenesis of type 2 diabetes. Using oligonucleotide microarrays and real-time PCR of pancreatic islets isolated from humans with type 2 diabetes versus normal glucose-tolerant controls, we identified multiple changes in expression of genes known to be important in beta cell function, including major decreases in expression of HNF4alpha, insulin receptor, IRS2, Akt2, and several glucose-metabolic-pathway genes. There was also a 90% decrease i ...[more]