Transcriptomics

Dataset Information

359

Transcription profiling of CD34+CD38- vs CD34+CD38+ fractions of human umbilical cord blood and comparison of slow-dividing fraction vs the fast dividing fraction of CD34+/CD38- population


ABSTRACT: Comparison of the CD34+CD38- versus CD34+CD38+ fractions of human umbilical cord blood and comparison of the slow-dividing fraction versus the fast dividing fraction of the CD34+/CD38- population.

INSTRUMENT(S): (Make:Axon Instruments,Model:GenePix 4000B)

ORGANISM(S): Homo sapiens  

SUBMITTER: Wolfgang Wagner  

PROVIDER: E-EMBL-1 | ArrayExpress | 2005-09-08

REPOSITORIES: ArrayExpress

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Publications

Retroviral integration sites correlate with expressed genes in hematopoietic stem cells.

Wagner Wolfgang W   Wagner Wolfgang W   Laufs Stephanie S   Blake Jonathon J   Schwager Christian C   Wu Xiaolin X   Zeller Jens W JW   Ho Anthony D AD   Fruehauf Stefan S  

Stem cells (Dayton, Ohio) 20050901 8


In this study, we analyzed whether retroviral integration sites in repopulating hematopoietic cells correlate with genes expressed in fractions enriched in hematopoietic stem cells (HSCs). We have previously described microarray studies of two populations enriched in HSCs: CD34+/CD38- and the slow dividing fraction of CD34+/CD38- cells (SDF). Furthermore, we demonstrated that oncoretroviral integrations in severe combined immunodeficient repopulating cells are preferentially located near the tra  ...[more]

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