Genomics

Dataset Information

123

MBD-Seq of human primary colorectal tumours to explore abnormal CGI methylation. EGA study.


ABSTRACT: A common hallmark of neoplastic cells is abnormal acquisition of CpG island (CGI) methylation and the silencing of associated gene promoters. To determine the extent and distribution of CGI methylation in colorectal cancer, we solexa sequenced MBD affinity purified DNA prepared from five colorectal tumours and matched colon mucosa from the same individuals.

INSTRUMENT(S): Illumina Genome Analyzer II

ORGANISM(S): Homo sapiens  

SUBMITTER: The Wellcome Trust Sanger Institute  

PROVIDER: E-ERAD-12 | ArrayExpress | 2012-08-01

SECONDARY ACCESSION(S): EGAS00001000076

REPOSITORIES: ArrayExpress

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