Transcriptomics

Dataset Information

300

RNA-seq of Trichuris muris in different developmental stages


ABSTRACT: Trichuris muris is very closely related to the human parasite T. trichiura sharing cross reactive antigens. Moreover, it is a remarkably tractable model system for dissecting immune responses and host parasite relationships and is actively being investigated in a number of laboratories worldwide. T. muris is a naturally occurring nematode parasite of mice which resides in the caecum and colon and has a direct oral faecal life cycle. High-throughput sequencing of Trichuris muris transcriptome for de novo assembly of transcripts. The main objective of this project is to recognize genes expressed in given life stages. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/

OTHER RELATED OMICS DATASETS IN: E-ERAD-181

INSTRUMENT(S): Illumina Genome Analyzer II

ORGANISM(S): Trichuris muris  

SUBMITTER: The Wellcome Trust Sanger Institute  

PROVIDER: E-ERAD-125 | ArrayExpress | 2013-05-28

SECONDARY ACCESSION(S): ERP002000

REPOSITORIES: ArrayExpress, ENA

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Publications


Whipworms are common soil-transmitted helminths that cause debilitating chronic infections in man. These nematodes are only distantly related to Caenorhabditis elegans and have evolved to occupy an unusual niche, tunneling through epithelial cells of the large intestine. We report here the whole-genome sequences of the human-infective Trichuris trichiura and the mouse laboratory model Trichuris muris. On the basis of whole-transcriptome analyses, we identify many genes that are expressed in a se  ...[more]

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