Transcriptomics

Dataset Information

3

Transcription profiling of mouse laser-microdissected motorneurons in a Spinal Muscular Atrophy model (SMA)


ABSTRACT: Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Stem cell transplantation could represent a therapeutic approach for motor neuron diseases such as SMA. We examined the theraputics effects of a spinal cord neural stem cell population and their ability to modify SMA phenotype. Microarray technology was used to assess the global gene expression profile of laser-microdissected motoneurons obtained by transplanted and veichle treated SMA, and wildtype mice. Experiment Overall Design: The microarray data derived from three different groups: wildtype controls (vehicle treated), transgenic SMA (vehicle treated) and transplanted SMA mice. Each population consists of three RNA profiling samples.

INSTRUMENT(S): 418 [Affymetrix]

SUBMITTER: Stefania Corti  

PROVIDER: E-GEOD-10224 | ArrayExpress | 2008-10-20

SECONDARY ACCESSION(S): GSE10224PRJNA108289

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-10224.2columns.txt Txt
E-GEOD-10224.2columns.xls Xls
E-GEOD-10224.README.txt Txt
E-GEOD-10224.biosamples.map Other
E-GEOD-10224.biosamples.png Other
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