Transcriptomics

Dataset Information

7

Transcription profiling of mouse striatal samples from wildtype, Hdh/Q80 animals


ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE9375: Striatal gene expression data from 12 months-old Hdh4/Q80 mice and control mice. GSE9857: Striatal gene expression data from 12 weeks-old R6/2 mice and control mice; GSE10202: Striatal gene expression data from 22-month-old CHL2 mice and control mice. Experiment Overall Design: Refer to individual Series

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: Alexandre Kuhn  

PROVIDER: E-GEOD-10263 | ArrayExpress | 2008-05-21

SECONDARY ACCESSION(S): GSE10263PRJNA108459

REPOSITORIES: GEO, ArrayExpress

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Publications


To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) and postmortem human HD caudate. Transgenic models expressing short N-terminal fragments of mutant huntingtin (R6/1 and R6/2 mice) exhibited the most rapid effects on gene expression, consistent with previous studies. Although changes in the bra  ...[more]

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