Dataset Information


H3K4me3 location in U937 cells

ABSTRACT: H3K4me3 enrichment at proximal promoter regions Keywords: ChIP-on-chip data We describe that RBP2 shows high correlation with the presence of H3K4me3. Biological replicates: chromatin immunoprecipitations were performed independently in parallel

ORGANISM(S): Homo sapiens  

SUBMITTER: Elizaveta V Benevolenskaya  

PROVIDER: E-GEOD-10635 | ArrayExpress | 2010-06-20



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Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation.

Lopez-Bigas Nuria N   Kisiel Tomasz A TA   Dewaal Dannielle C DC   Holmes Katie B KB   Volkert Tom L TL   Gupta Sumeet S   Love Jennifer J   Murray Heather L HL   Young Richard A RA   Benevolenskaya Elizaveta V EV  

Molecular cell 20080801 4

Retinoblastoma protein (pRB) mediates cell-cycle withdrawal and differentiation by interacting with a variety of proteins. RB-Binding Protein 2 (RBP2) has been shown to be a key effector. We sought to determine transcriptional regulation by RBP2 genome-wide by using location analysis and gene expression profiling experiments. We describe that RBP2 shows high correlation with the presence of H3K4me3 and its target genes are separated into two functionally distinct classes: differentiation-indepen  ...[more]

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