Transcriptomics,Multiomics

Dataset Information

4

HS-R5


ABSTRACT: 14 days hindlimb suspended, 5 days reloaded m. soleus RNA was isolated from cryosections using RNeasy kit (Qiagen). 5 microgram total RNA was subjected to microarray analysis.

OTHER RELATED OMICS DATASETS IN: PRJNA87613PRJNA94371PRJNA104735

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Dominique Desplanches   Hans Hoppeler  Silvia Schmutz  Martin Flück  Matthias Wittwer 

PROVIDER: E-GEOD-1084 | ArrayExpress | 2010-06-06

SECONDARY ACCESSION(S): GSE1084PRJNA104735

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-1084.README.txt Txt
E-GEOD-1084.biosamples.map Other
E-GEOD-1084.biosamples.png Other
E-GEOD-1084.biosamples.svg Svg
E-GEOD-1084.idf.txt Idf
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Publications

Transcriptional reprogramming during reloading of atrophied rat soleus muscle.

Flück Martin M   Schmutz Silvia S   Wittwer Matthias M   Hoppeler Hans H   Desplanches Dominique D  

American journal of physiology. Regulatory, integrative and comparative physiology 20050701 1


The hypothesis was tested that differential, coregulated transcriptional adaptations of various cellular pathways would occur early with increased mechanical loading of atrophied skeletal muscle and relate to concurrent damage of muscle fibers. Atrophy and slow-to-fast fiber transformation of rat soleus muscle was provoked by 14 days of hindlimb suspension (HS). Subsequent reloading of hindlimbs caused a fourfold increase in the percentage of muscle fibers, demonstrating endomysial tenascin-C st  ...[more]

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