Transcriptomics

Dataset Information

2

In vivo endothelial transcriptional profiles of porcine coronary and iliac arteries


ABSTRACT: Phenotypic heterogeneity among arterial ECs is particularly relevant to atherosclerosis since the disease occurs predominantly in major arteries, which vary in their atherosusceptibility. To explore EC heterogeneity, we used DNA microarrays to compare gene expression profiles of freshly harvested porcine coronary and iliac artery ECs. We demonstrate that in vivo the endothelial transcriptional profile of a coronary artery (the right coronary artery) is intrinsically different from that of a major conduit vessel (the external iliac artery), and that this difference is consistent with former vessel being more prone to atherosclerosis. Keywords: coronary atherosclerosis, endothelial heterogeneity, microarray, gene expression Endothelial cells were freshly harvest from right coronary, left and right iliac arteries from four pigs. RNA were isolated and expression profiles were obtained using olig microarrays.

ORGANISM(S): Sus scrofa  

SUBMITTER: Morton H Friedman  Kelley A Burridge  Ji Zhang 

PROVIDER: E-GEOD-10938 | ArrayExpress | 2010-06-20

SECONDARY ACCESSION(S): GSE10938PRJNA107249

REPOSITORIES: GEO, ArrayExpress

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Publications

In vivo differences between endothelial transcriptional profiles of coronary and iliac arteries revealed by microarray analysis.

Zhang Ji J   Burridge Kelley A KA   Friedman Morton H MH  

American journal of physiology. Heart and circulatory physiology 20080808 4


Endothelial cells (ECs) from different vascular beds display a remarkable heterogeneity in both structure and function. Phenotypic heterogeneity among arterial ECs is particularly relevant to atherosclerosis since the disease occurs predominantly in major arteries, which vary in their atherosusceptibility. To explore EC heterogeneity between typical atheroprone and atheroresistant arteries, we used DNA microarrays to compare gene expression profiles of freshly harvested porcine coronary (CECs) a  ...[more]

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