Transcriptomics

Dataset Information

47

Microarray analaysis of adult and childhood renal tumors.


ABSTRACT: Analysis of adult and childhood tumors reveals activation of an E2F3 signature unique to Wilms tumors. Keywords: Disease state analysis Clear cell, chromophobe, papillary (types 1 and 2), oncocytoma, and Wilms tumor were compared to normal kidney tissue. No technical replicates.

ORGANISM(S): Homo sapiens  

SUBMITTER: Eric Kort  Eric J Kort 

PROVIDER: E-GEOD-11024 | ArrayExpress | 2008-06-05

SECONDARY ACCESSION(S): GSE11024PRJNA107121

REPOSITORIES: GEO, ArrayExpress

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Publications

The E2F3-Oncomir-1 axis is activated in Wilms' tumor.

Kort Eric J EJ   Farber Leslie L   Tretiakova Maria M   Petillo David D   Furge Kyle A KA   Yang Ximing J XJ   Cornelius Albert A   Teh Bin T BT  

Cancer research 20080601 11


Oncomir-1 is an oncogenic cluster of microRNAs (miRNA) located on chromosome 13. Previous in vitro studies showed that it is transcriptionally regulated by the transcription factor E2F3. In this report, we combine expression profiling of both mRNA and miRNAs in Wilms' tumor (WT) samples to provide the first evidence that the E2F3-Oncomir-1 axis, previously identified in cell culture, is deregulated in primary human tumors. Analysis of RNA expression signatures showed that an E2F3 gene signature  ...[more]

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