Transcriptomics

Dataset Information

0

Study of HepG2 cells transduced with HBX expressing recombinant Adenoviruses (AdHBx) and treated with UV


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE11064: AdHBx UV vs AdEasy UV vs HepG2 GSE11106: Chromatin Immunoprecipitation of UV treated AdHBx cells with anti-HBx antibodies Keywords: SuperSeries One-condition experiment, AdHBx (experimental) UV vs AdEasy (vector control) UV. HepG2 cells were infected with either recombinant HBx adenoviruses (AdHBx) or control adenoviruses (AdEasy). Seventy-two hours later, infected cells were exposed for 30 seconds to UVC (254 nm) irradiation with a germicidal lamp calibrated to deliver 8 or 16 J/m2. Cells were then harvested for either ChIP-chip profiling or expression microarray profiling.

ORGANISM(S): Homo sapiens  

SUBMITTER: Wah Heng Lee 

PROVIDER: E-GEOD-11108 | ArrayExpress | 2008-07-01

SECONDARY ACCESSION(S): GSE11108PRJNA106995

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-11108.README.txt Txt
E-GEOD-11108.biosamples.map Other
E-GEOD-11108.biosamples.png Other
E-GEOD-11108.biosamples.svg Svg
E-GEOD-11108.idf.txt Idf
Items per page:
1 - 5 of 11
altmetric image

Publications

Deregulated direct targets of the hepatitis B virus (HBV) protein, HBx, identified through chromatin immunoprecipitation and expression microarray profiling.

Sung Wing-Kin WK   Lu Yiwei Y   Lee Charlie W H CWH   Zhang Dongwei D   Ronaghi Mostafa M   Lee Caroline G L CGL  

The Journal of biological chemistry 20090513 33


The hepatitis B-X (HBx) protein is strongly associated with hepatocellular carcinoma. It is implicated not to directly cause cancer but to play a role in hepatocellular carcinoma as a co-factor. The oncogenic potential of HBx primarily lies in its interaction with transcriptional regulators resulting in aberrant gene expression and deregulated cellular pathways. Utilizing ultraviolet irradiation to simulate a tumor-initiating event, we integrated chip-based chromatin immunoprecipitation (ChIP-ch  ...[more]

Similar Datasets

2008-10-21 | E-GEOD-11064 | ArrayExpress
2008-07-01 | E-GEOD-11106 | ArrayExpress
2008-07-01 | GSE11106 | GEO
2008-07-01 | GSE11064 | GEO
2016-06-22 | GSE64877 | GEO
2016-06-22 | GSE64875 | GEO
2008-07-01 | GSE11108 | GEO
2006-01-01 | S-EPMC4087832 | BioStudies
2010-05-24 | E-GEOD-17474 | ArrayExpress
2010-05-24 | GSE17474 | GEO