Transcriptomics,Multiomics

Dataset Information

5

Regulation by the homologous Ace2 and Swi5 factors of Saccharomyces cerevisiae


ABSTRACT: The homologous Ace2 and Swi5 transcription factors of Saccharomyces cerevisiae have identical DNA-binding domains, and both are cell cycle regulated. There are common target genes, as well as genes activated only by Ace2 and other genes activated only by Swi5. Keywords: genetic modification RNA was isolated from four strains: wild type, ace2 gene deletion, swi5 gene deletion, and the ace2 swi5 double gene deletion. RNAs from the three mutant strains were compared to wild type RNA in a microarray hybridization experiment.

OTHER RELATED OMICS DATASETS IN: PRJNA106493

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: David J Stillman   Warren P Voth  Shinya Takahata  Yaxin Yu  Rebecca L Parker  Kelsi L Kretschmann  David Stillman  Brett Milash  Jason D Lieb 

PROVIDER: E-GEOD-11380 | ArrayExpress | 2008-05-13

SECONDARY ACCESSION(S): GSE11380PRJNA106493

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-11380.README.txt Txt
E-GEOD-11380.idf.txt Idf
E-GEOD-11380.processed.1.zip Processed
E-GEOD-11380.raw.1.zip Raw
E-GEOD-11380.sdrf.txt Txt
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Publications

Forkhead proteins control the outcome of transcription factor binding by antiactivation.

Voth Warren P WP   Yu Yaxin Y   Takahata Shinya S   Kretschmann Kelsi L KL   Lieb Jason D JD   Parker Rebecca L RL   Milash Brett B   Stillman David J DJ  

The EMBO journal 20070927 20


Transcription factors with identical DNA-binding specificity often activate different genes in vivo. Yeast Ace2 and Swi5 are such activators, with targets we classify as Swi5-only, Ace2-only, or both. We define two unique regulatory modes. Ace2 and Swi5 both bind in vitro to Swi5-only genes such as HO, but only Swi5 binds and activates in vivo. In contrast, Ace2 and Swi5 both bind in vivo to Ace2-only genes, such as CTS1, but promoter-bound Swi5 fails to activate. We show that activation by Swi5  ...[more]

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