Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA106493
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: David J Stillman Warren P Voth Shinya Takahata Yaxin Yu Rebecca L Parker Kelsi L Kretschmann David Stillman Brett Milash Jason D Lieb
PROVIDER: E-GEOD-11380 | ArrayExpress | 2008-05-13
SECONDARY ACCESSION(S): GSE11380PRJNA106493
REPOSITORIES: GEO, ArrayExpress
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E-GEOD-11380.README.txt | Txt | |||
E-GEOD-11380.idf.txt | Idf | |||
E-GEOD-11380.processed.1.zip | Processed | |||
E-GEOD-11380.raw.1.zip | Raw | |||
E-GEOD-11380.sdrf.txt | Txt |
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Voth Warren P WP Yu Yaxin Y Takahata Shinya S Kretschmann Kelsi L KL Lieb Jason D JD Parker Rebecca L RL Milash Brett B Stillman David J DJ
The EMBO journal 20070927 20
Transcription factors with identical DNA-binding specificity often activate different genes in vivo. Yeast Ace2 and Swi5 are such activators, with targets we classify as Swi5-only, Ace2-only, or both. We define two unique regulatory modes. Ace2 and Swi5 both bind in vitro to Swi5-only genes such as HO, but only Swi5 binds and activates in vivo. In contrast, Ace2 and Swi5 both bind in vivo to Ace2-only genes, such as CTS1, but promoter-bound Swi5 fails to activate. We show that activation by Swi5 ...[more]