Dataset Information


Transcriptional Response of Candida albicans Cells Following Phagocytosis by Mouse Macrophages

ABSTRACT: Transcriptional profiling of Candida albicans that had been phagocytosed for 1, 2, or 4 hours by either bone marrow-derived mouse macrophaged (BMDM) or immortalized RAW264.7 cells Keywords: Time course Two-condition experiment, phagocytosed cells vs cells maintained in D-10 media. Time course: 1, 2, and 4 hours. Biological replicates: 4 independent experiments at each cell-time combinations.

ORGANISM(S): Candida albicans  

SUBMITTER: Anne Marcil   Malcolm Whiteway  Andre Nantel  Josee Ash  Christine Gadoury  Jianchun Zhang 

PROVIDER: E-GEOD-11399 | ArrayExpress | 2008-07-28



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Analysis of PRA1 and its relationship to Candida albicans- macrophage interactions.

Marcil A A   Gadoury C C   Ash J J   Zhang J J   Nantel A A   Whiteway M M  

Infection and immunity 20080714 9

Phagocytosis of Candida albicans by either primary bone marrow-derived mouse macrophages or RAW 264.7 cells upregulated transcription of PRA1, which encodes a cell wall/membrane-associated antigen previously described as a fibrinogen binding protein. However, a pra1 null mutant was still able to bind fibrinogen, showing that Pra1p is not uniquely required for fibrinogen binding. As well, Pra1 tagged with green fluorescent protein did not colocalize with AlexaFluor 546-labeled human fibrinogen, a  ...[more]

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