Transcriptomics

Dataset Information

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Circadian Rhythm of Gene Expression Patterns in Liver of Mouse


ABSTRACT: Genes encoding the circadian pacemaker in the hypothalamic suprachiasmatic nuclei (SCN) of mammals have recently been identified, but the molecubasis of circadian timing in peripheral tissue is not well understood. We used a bead-based microarray to identify mouse liver transcripts that show circadian cycles of abundance under constant conditions. Keywords: Time course microarray-based expression profiling of mRNA with triplicates in mouse liver for 48 hours at 4-hour intervals

ORGANISM(S): Mus musculus  

SUBMITTER: Y J Na  YoungJi Na  J H Kim 

PROVIDER: E-GEOD-11516 | ArrayExpress | 2009-08-31

SECONDARY ACCESSION(S): GSE11516PRJNA106349

REPOSITORIES: GEO, ArrayExpress

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Publications

Comprehensive analysis of microRNA-mRNA co-expression in circadian rhythm.

Na Young Ji YJ   Sung Jung Hwan JH   Lee Suk Chan SC   Lee Young Ju YJ   Choi Yeun Joo YJ   Park Woong Yang WY   Shin Hee Sup HS   Kim Ju Han JH  

Experimental & molecular medicine 20090901 9


To investigate the potential role of microRNA (miRNA) in the regulation of circadian rhythm, we performed microarray-based expression profiling study of both miRNA and mRNA in mouse liver for 48 h at 4-hour intervals. Circadian miRNA-mRNA target pair is defined as the pair both elements of which show circadian expression patterns and the sequence-based target relationship of which can be predicted. Circadian initiators, Clock and Bmal1, showed inversely correlated circadian expression patterns a  ...[more]

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