Transcriptomics

Dataset Information

5

Analysis of gene expression in different T cell clones


ABSTRACT: The aim was to analyze the expression of genes in T cell clones having different functional profiles (Th1, Th0, Th17, Th2) obtained from the same individual. Keywords: Gene expression, T cell clones, Th17 characterisation The T cell clones were derived according to well known protocol, using different cytokines, and classified on the basis of their ability to produce cytokines. Once characterized for their production of IL-4, IL-12, gamma-IFN, IL-13, IL-1, they were used to prepare microarray experiments.

ORGANISM(S): Homo sapiens  

SUBMITTER: Francesco Annunziato   Raffaele De Palma  Lorenzo Cosmi  Gabriella Rodolico 

PROVIDER: E-GEOD-11553 | ArrayExpress | 2008-05-30

SECONDARY ACCESSION(S): GSE11553PRJNA106281

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications


We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T helper cell (Th17) clones and that all IL-17-producing cells are contained in the CD161(+) fraction of CD4(+) T cells present in the circulation or in inflamed tissues, although they are not CD1-restricted natural killer T cells. More importantly, we show that all IL-17-producing cells originate from CD161(+) naive CD4(+) T cells of umbilical cord blood, as well as of the postnatal thymus, in response to the c  ...[more]

Similar Datasets

2010-07-01 | E-GEOD-22642 | ArrayExpress
2010-05-19 | E-GEOD-15867 | ArrayExpress
2008-05-30 | GSE11553 | GEO
2010-11-18 | E-GEOD-25125 | ArrayExpress
| GSE104023 | GEO
2012-04-07 | E-GEOD-28482 | ArrayExpress
2012-09-01 | E-GEOD-39820 | ArrayExpress
2010-07-01 | GSE22642 | GEO
2011-09-01 | E-MEXP-3299 | ArrayExpress
2008-09-04 | E-GEOD-11112 | ArrayExpress