Proteomics

Dataset Information

5

Discovery of the targets of the immune response to chronic lymphocytic leukemia in 2 patients using protein microarrays


ABSTRACT: The binding of serum immunoglobulins to proteins was compared using serum from after and before an immunotherapeutic intervention (donor lymphocyte infusion) in two patients who had relapsed chronic lymphocytic leukemia (CLL) after bone marrow transplant. One Invitrogen ProtoArray was used for each sample. Significant interactions were determined by comparing the before and after samples for each patient separately, using the Concentration-Dependent Analysis described in Marina et al., J Proteome Res, 2008. One sample from before and one sample from after immunotherapy were tested for each patient. Keywords: Immune response discovery One sample from before and one sample from after immunotherapy were tested for each patient.

ORGANISM(S): Homo sapiens  

SUBMITTER: Ovidiu Marina  

PROVIDER: E-GEOD-11564 | ArrayExpress | 2008-05-31

SECONDARY ACCESSION(S): GSE11564PRJNA109143

REPOSITORIES: GEO, ArrayExpress

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Publications


Patients with chronic lymphocytic leukemia (CLL) who relapse after allogeneic transplant may achieve durable remission following donor lymphocyte infusion (DLI), showing the potency of donor-derived immunity in eradicating tumors. We sought to elucidate the antigenic basis of the effective graft-versus-leukemia (GvL) responses associated with DLI for the treatment of CLL by analyzing the specificity of plasma antibody responses developing in two DLI-treated patients who achieved long-term remiss  ...[more]

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