Dataset Information


Melan-a melanocytes and B16 melanoma cells

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE11580: Time course RA-treatment of B16 mouse melanoma cells GSE11584: Melan-a mouse melanocytes vs. B16 mouse melanoma cells Keywords: SuperSeries Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: James Denvir  

PROVIDER: E-GEOD-11588 | ArrayExpress | 2008-07-31



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Global analysis of gene expression changes during retinoic acid-induced growth arrest and differentiation of melanoma: comparison to differentially expressed genes in melanocytes vs melanoma.

Estler Mary M   Boskovic Goran G   Denvir James J   Miles Sarah S   Primerano Donald A DA   Niles Richard M RM  

BMC genomics 20081011

The incidence of malignant melanoma has significantly increased over the last decade. Some of these malignancies are susceptible to the growth inhibitory and pro-differentiating effects of all-trans-retinoic acid (RA). The molecular changes responsible for the biological activity of RA in melanoma are not well understood.In an analysis of sequential global gene expression changes during a 4-48 h RA treatment of B16 mouse melanoma cells, we found that RA increased the expression of 757 genes and  ...[more]

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