Genomics,Multiomics

Dataset Information

4

Transcription profiling of human ectopic endometrium and peritoneal tissues in nude mice


ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE11691: Euctopic and ectopic human endometrium (endometriosis); GSE11768: Nude mouse model of endometriosis Experiment Overall Design: Refer to individual Series

OTHER RELATED OMICS DATASETS IN: PRJNA105951PRJNA109165PRJNA109079

ORGANISM(S): Musculus  

SUBMITTER: D Stephen Charnock-Jones  

PROVIDER: E-GEOD-11769 | ArrayExpress | 2009-01-02

SECONDARY ACCESSION(S): GSE11769PRJNA105951

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-11769.2columns.txt Txt
E-GEOD-11769.2columns.xls Xls
E-GEOD-11769.README.txt Txt
E-GEOD-11769.biosamples.map Other
E-GEOD-11769.biosamples.png Other
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Publications

Endometrial-peritoneal interactions during endometriotic lesion establishment.

Hull M Louise ML   Escareno Claudia Rangel CR   Godsland Jane M JM   Doig John R JR   Johnson Claire M CM   Phillips Stephen C SC   Smith Stephen K SK   Tavaré Simon S   Print Cristin G CG   Charnock-Jones D Stephen DS  

The American journal of pathology 20080807 3


The pathophysiology of endometriosis remains unclear but involves a complex interaction between ectopic endometrium and host peritoneal tissues. We hypothesized that disruption of this interaction would suppress endometriotic lesion formation. We hoped to delineate the molecular and cellular dialogue between ectopic human endometrium and peritoneal tissues in nude mice as a first step toward testing this hypothesis. Human endometrium was xenografted into nude mice, and the resulting lesions were  ...[more]

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