Transcriptomics

Dataset Information

5

Human scrotum and labia majora samples treated with DHT and/or AZA


ABSTRACT: Human scrotum and labia majora samples treated with DHT and/or AZA A compound treatment design type is where the response to administration of a compound or chemical (including biological compounds such as hormones) is assayed. Compound Based Treatment: dihydrotestosterone (DHT), 5-aza-deoxy-cytidine (AZA), none or both Cell Line: normal scrotum or labia majora derived from complete androgen insensitivity syndrome due to inactivating mutation of the androgen receptor gene Computed

ORGANISM(S): Homo sapiens  

SUBMITTER: Paul-Martin Holterhus  

PROVIDER: E-GEOD-11847 | ArrayExpress | 2009-05-20

SECONDARY ACCESSION(S): GSE11847PRJNA105641

REPOSITORIES: GEO, ArrayExpress

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Publications

Apolipoprotein D (APOD) is a putative biomarker of androgen receptor function in androgen insensitivity syndrome.

Appari Mahesh M   Werner Ralf R   Wünsch Lutz L   Cario Gunnar G   Demeter Janos J   Hiort Olaf O   Riepe Felix F   Brooks James D JD   Holterhus Paul-Martin PM  

Journal of molecular medicine (Berlin, Germany) 20090330 6


Androgen insensitivity syndrome (AIS) is the most common cause of disorders of sex development usually caused by mutations in the androgen receptor (AR) gene. AIS is characterized by a poor genotype-phenotype correlation, and many patients with clinically presumed AIS do not seem to have mutations in the AR gene. We therefore aimed at identifying a biomarker enabling the assessment of the cellular function of the AR as a transcriptional activator. In the first step, we used complementary DNA (cD  ...[more]

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