Transcriptomics

Dataset Information

5

Transcription profiling of human cholangiocarcinoma cells (cholangiocytes) expressing IL-6


ABSTRACT: The association between chronic inflammation and the development and progression of malignancy is exemplified in the biliary tract where persistent inflammation strongly predisposes to cholangiocarcinoma. The inflammatory cytokine interleukin-6 (IL-6) enhances tumor growth in cholangiocarcinoma by altered gene expression via autocrine mechanisms. We therefore investigated the effect of chronic exposure to IL-6 on gene expression using malignant cholangiocytes stably transfected to overexpress IL-6. Comparison of gene expression identified several genes that were altered by enforced IL-6 expression. Experiment Overall Design: Mz-ChA-1 cells were stably transfected with a pTarget vector plasmid containing full length IL-6 under the control of a CMV promoter to generate Mz-IL6. Cells transfected with empty vector were used as control

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Tushar Patel  

PROVIDER: E-GEOD-11883 | ArrayExpress | 2008-10-21

SECONDARY ACCESSION(S): GSE11883PRJNA105701

REPOSITORIES: GEO, ArrayExpress

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Publications

Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression.

Wehbe Hania H   Henson Roger R   Meng Fanyin F   Mize-Berge Janna J   Patel Tushar T  

Cancer research 20061101 21


The association between chronic inflammation and the development and progression of malignancy is exemplified in the biliary tract where persistent inflammation strongly predisposes to cholangiocarcinoma. The inflammatory cytokine interleukin-6 (IL-6) enhances tumor growth in cholangiocarcinoma by altered gene expression via autocrine mechanisms. IL-6 can regulate the activity of DNA methyltransferases, and moreover, aberrant DNA methylation can contribute to carcinogenesis. We therefore investi  ...[more]

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