Transcriptomics

Dataset Information

63

Bacillus subtilis 168 cells: ccpN mutant and ccpN-yqfL double mutant analysis


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE11873: Bacillus subtilis 168 cells: wild-type vs. ccpN (non polar) GSE11876: Bacillus subtilis 168 cells: wild-type vs. (ccpN-yqfL) double mutant Refer to individual Series

ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168  

SUBMITTER: Thierry Doan  

PROVIDER: E-GEOD-11937 | ArrayExpress | 2008-07-01

SECONDARY ACCESSION(S): GSE11937PRJNA105789

REPOSITORIES: GEO, ArrayExpress

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Publications

CcpN controls central carbon fluxes in Bacillus subtilis.

Tännler Simon S   Fischer Eliane E   Le Coq Dominique D   Doan Thierry T   Jamet Emmanuel E   Sauer Uwe U   Aymerich Stéphane S  

Journal of bacteriology 20080627 18


The transcriptional regulator CcpN of Bacillus subtilis has been recently characterized as a repressor of two gluconeogenic genes, gapB and pckA, and of a small noncoding regulatory RNA, sr1, involved in arginine catabolism. Deletion of ccpN impairs growth on glucose and strongly alters the distribution of intracellular fluxes, rerouting the main glucose catabolism from glycolysis to the pentose phosphate (PP) pathway. Using transcriptome analysis, we show that during growth on glucose, gapB and  ...[more]

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