Transcriptomics

Dataset Information

69

Analysis of HeLa cells after transfection with miR-1, miR-124 and miR-181.


ABSTRACT: Analysis of HeLa cells at 24 hours after transfection with wild type miR-1, miR-124, miR-181 versus control transfected HeLa cells. Results were compared to protein down-regulation at 48 hours measured by SILAC-MS. Analysis of HeLa cells at 24 hours after transfection with wild type miR-1, miR-124, miR-181 versus control transfected HeLa cells. Results were compared to protein down-regulation at 48 hours measured by SILAC-MS.

ORGANISM(S): Homo sapiens  

SUBMITTER: Fernando Camargo   Judit Villén  David Bartel  Steven Gygi  Daehyun Baek  Whitehead Institute  Chanseok Shin 

PROVIDER: E-GEOD-11968 | ArrayExpress | 2010-05-25

SECONDARY ACCESSION(S): GSE11968PRJNA113833

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

The impact of microRNAs on protein output.

Baek Daehyun D   Villén Judit J   Shin Chanseok C   Camargo Fernando D FD   Gygi Steven P SP   Bartel David P DP  

Nature 20080730 7209


MicroRNAs are endogenous approximately 23-nucleotide RNAs that can pair to sites in the messenger RNAs of protein-coding genes to downregulate the expression from these messages. MicroRNAs are known to influence the evolution and stability of many mRNAs, but their global impact on protein output had not been examined. Here we use quantitative mass spectrometry to measure the response of thousands of proteins after introducing microRNAs into cultured cells and after deleting mir-223 in mouse neut  ...[more]

Similar Datasets

| GSE11968 | GEO
2013-12-02 | E-GEOD-52530 | ArrayExpress
| PRJNA113833 | ENA
2006-11-03 | GSE6207 | GEO
2010-06-20 | E-GEOD-18835 | ArrayExpress
2007-11-01 | E-GEOD-6207 | ArrayExpress
2016-03-24 | E-MTAB-4602 | ArrayExpress
2014-10-28 | PXD001260 | Pride
2009-11-10 | GSE18835 | GEO
2019-05-10 | E-MTAB-7455 | ArrayExpress