Transcriptomics

Dataset Information

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Glycan effect on Saccharolytic Human Distal Gut Symbiont, B. thetaiotaomicron


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE11944: Mucosal Glycan Foraging Enhances the Fitness and Transmission of a Saccharolytic Human Distal Gut Symbiont GSE11953: Mucosal Glycan Foraging Enhances the Fitness and Transmission of a Saccharolytic Human Distal Gut Symbiont: ECF mutant GSE11962: Growth of B. thetaiotaomicron on purified host mucosal glycans and glycan fragments Refer to individual Series

ORGANISM(S): Bacteroides thetaiotaomicron  

SUBMITTER: Eric Charles Martens  

PROVIDER: E-GEOD-11980 | ArrayExpress | 2008-11-20

SECONDARY ACCESSION(S): GSE11980PRJNA105861

REPOSITORIES: GEO, ArrayExpress

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Publications

Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont.

Martens Eric C EC   Chiang Herbert C HC   Gordon Jeffrey I JI  

Cell host & microbe 20081101 5


The distal human gut is a microbial bioreactor that digests complex carbohydrates. The strategies evolved by gut microbes to sense and process diverse glycans have important implications for the assembly and operation of this ecosystem. The human gut-derived bacterium Bacteroides thetaiotaomicron forages on both host and dietary glycans. Its ability to target these substrates resides in 88 polysaccharide utilization loci (PULs), encompassing 18% of its genome. Whole genome transcriptional profil  ...[more]

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