Transcriptomics

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Transcription profiling by array of human chromophobe renal cell carcinoma and oncocytoma


ABSTRACT: This study aims to compare gene expression profiles of chromophobe renal cell carcinoma (RCC) and benign oncocytoma, aiming at identifying differentially expressed genes. Experiment Overall Design: Nine cases each of chromophobe RCC and oncocytoma were analyzed by oligonucleotide microarray. Candidate genes that showed consistent differential expression were validated by RT-PCR using 25 fresh-frozen and 15 formalin-fixed paraffin-embedded tumor samples. Immunohistochemical analysis was also performed for two selected gene products, Claudin 8 and MAL2.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Piali Mukherjee  

PROVIDER: E-GEOD-12090 | ArrayExpress | 2008-10-21

SECONDARY ACCESSION(S): GSE12090PRJNA113527

REPOSITORIES: GEO, ArrayExpress

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Publications

Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes.

Rohan Stephen S   Tu Jiangling J JJ   Kao Jean J   Mukherjee Piali P   Campagne Fabien F   Zhou Xi K XK   Hyjek Elizabeth E   Alonso Miguel A MA   Chen Yao-Tseng YT  

Clinical cancer research : an official journal of the American Association for Cancer Research 20061201 23


PURPOSE: To compare gene expression profiles of chromophobe renal cell carcinoma (RCC) and benign oncocytoma, aiming at identifying differentially expressed genes. EXPERIMENTAL DESIGN: Nine cases each of chromophobe RCC and oncocytoma were analyzed by oligonucleotide microarray. Candidate genes that showed consistent differential expression were validated by reverse transcription-PCR using 25 fresh-frozen and 15 formalin-fixed, paraffin-embedded tumor samples. Immunohistochemical analysis was al  ...[more]

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