Transcriptomics

Dataset Information

5

Aging Time course


ABSTRACT: RNA was isolated from age-synchronous cultures of hermaphrodite worms grown at 25?C at 2, 5, 8, or 11 days of adulthood. We observed no deaths in the worm population at days 2 and 5 of adulthood, 30% at day 8 and 93% death at day 11. The aging time course was repeated four times. Groups of assays that are related as part of a time series. Age: Age of adult worms (days) Keywords: time_series_design User Defined

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Min Jiang   Stuart Kim 

PROVIDER: E-GEOD-12168 | ArrayExpress | 2008-07-29

SECONDARY ACCESSION(S): GSE12168PRJNA114323

REPOSITORIES: GEO, ArrayExpress

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Publications

An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans.

Budovskaya Yelena V YV   Wu Kendall K   Southworth Lucinda K LK   Jiang Min M   Tedesco Patricia P   Johnson Thomas E TE   Kim Stuart K SK  

Cell 20080701 2


To define the C. elegans aging process at the molecular level, we used DNA microarray experiments to identify a set of 1294 age-regulated genes and found that the GATA transcription factors ELT-3, ELT-5, and ELT-6 are responsible for age regulation of a large fraction of these genes. Expression of elt-5 and elt-6 increases during normal aging, and both of these GATA factors repress expression of elt-3, which shows a corresponding decrease in expression in old worms. elt-3 regulates a large numbe  ...[more]

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