Transcriptomics,Multiomics

Dataset Information

2

Changes in cardiac transcription profiles following off-pump coronary revascularization surgery


ABSTRACT: To investigate changes in cardiac transcription profiles caused by off-pump cardiac surgery, we collected myocardial samples, prior and after grafting, from patients undergoing off-pump coronary revascularization surgery. The transcriptional profile of the mRNA in these samples was measured with gene array technology. Changes in transcriptional profiles can be correlated with the stress response of heart to off-pump surgery. Keywords: human, cardiac, OPCAB coronary surgery, gene expression. Myocardial samples were collected, prior and after grafting, from patients undergoing off-pump coronary artery bypass grafting.

OTHER RELATED OMICS DATASETS IN: PRJNA114217PRJNA114215PRJNA113251

ORGANISM(S): Homo sapiens  

SUBMITTER: Amir Mokhtari   Massimo Caputo  Mohamed T. Ghorbel  Myriam Cherif  Gianni D Angelini  Mohamed T Ghorbel 

PROVIDER: E-GEOD-12485 | ArrayExpress | 2010-07-07

SECONDARY ACCESSION(S): GSE12485PRJNA114215

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-12485.README.txt Txt
E-GEOD-12485.eSet.r Other
E-GEOD-12485.idf.txt Idf
E-GEOD-12485.processed.1.zip Processed
E-GEOD-12485.raw.1.zip Raw
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Publications

Off-pump coronary artery bypass surgery is associated with fewer gene expression changes in the human myocardium in comparison with on-pump surgery.

Ghorbel Mohamed T MT   Cherif Myriam M   Mokhtari Amir A   Bruno Vito Domenico VD   Caputo Massimo M   Angelini Gianni D GD  

Physiological genomics 20100323 1


Off-pump coronary artery bypass surgery reduces the myocardial injury associated with on pump surgery with cardiopulmonary bypass (CPB) and ischemic-cardioplegic arrest (CA). We sought to find a mechanistic explanation for this by comparing the transcriptomic changes in the myocardium of patients undergoing on- and off-pump surgery. Transcriptomic analyses were performed on left ventricular biopsies obtained from patients prior to (pre-op) and after completion of all coronary anastomoses (post-o  ...[more]

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