Transcriptomics

Dataset Information

5

Activity of the Bacillus anthracis 20 kDa protective antigen component


ABSTRACT: Edema factor of anthrax binds to the protective antigen (PA83) which cleaves to PA63 and PA20. The role of PA20 was examined using highthroughput gene expression analysis of human peripheral blood mononuclear cells (PBMC) exposed to PA20. Keywords: Toxicity determination PBMC obtained from different individuals over 6 monthes were incubated with and without rPA20

ORGANISM(S): Homo sapiens  

SUBMITTER: Rasha Hammamieh   M Jett  G Abshire  J Ezzell  W Ribot  R Hammamieh 

PROVIDER: E-GEOD-12533 | ArrayExpress | 2008-08-26

SECONDARY ACCESSION(S): GSE12533PRJNA112885

REPOSITORIES: GEO, ArrayExpress

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Publications

Activity of the Bacillus anthracis 20 kDa protective antigen component.

Hammamieh Rasha R   Ribot Wilson J WJ   Abshire Terry G TG   Jett Marti M   Ezzell John J  

BMC infectious diseases 20080922


BACKGROUND: Anthrax is caused by Bacillus anthracis that produce two exotoxins, lethal toxin and edema toxin. The lethal toxin is composed of the lethal factor (LF) complexed with the cell binding protective antigen (PA83, 83 kDa). Likewise, the edema factor (EF) binds to the PA83 to form the edema toxin. Once PA83 is bound to the host cell surface, a furin-like protease cleaves the full-length, inactive protein into 63 kDa and 20 kDa antigens (PA63 and PA20). PA63 forms a heptamer and is intern  ...[more]

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