Transcriptomics

Dataset Information

4

Microarray analysis of Huh7 cells treated with IFNa2, OSM or IFNa2 combined with OSM


ABSTRACT: OSM increases the antiviral effect of IFNα in Huh7 cells infected with hepatitis A virus (HAV) or HCV replicon and synergizes with IFNα in the induction of antiviral genes 16 samples. Four replicates for each experimental condition. 72 hours of treatment in DMEM supplemented with 2% FBS.

ORGANISM(S): Homo sapiens  

SUBMITTER: Jesus Prieto   Iranzu González  Rafael Aldabe  Pablo Sarobe  Iranzu Gonzalez  Esther Larrea  Victor Segura 

PROVIDER: E-GEOD-13046 | ArrayExpress | 2009-01-20

SECONDARY ACCESSION(S): GSE13046PRJNA109957

REPOSITORIES: GEO, ArrayExpress

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Publications

Oncostatin M enhances the antiviral effects of type I interferon and activates immunostimulatory functions in liver epithelial cells.

Larrea Esther E   Aldabe Rafael R   Gonzalez Iranzu I   Segura Victor V   Sarobe Pablo P   Echeverria Itziar I   Prieto Jesus J  

Journal of virology 20090121 7


Oncostatin M (OSM) is released together with type I interferon (IFN) by activated dendritic cells, suggesting a concerted action of these cytokines in the biological response against infection. We found that OSM increases the antiviral effect of IFN-alpha in Huh7 hepatoma cells infected with hepatitis A or hepatitis C virus and synergizes with IFN-alpha in the induction of antiviral genes. The combination of OSM and IFN-alpha led to upregulation of both STAT1 and STAT3 together with intense and  ...[more]

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