Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jesus Prieto Iranzu González Rafael Aldabe Pablo Sarobe Iranzu Gonzalez Esther Larrea Victor Segura
PROVIDER: E-GEOD-13046 | ArrayExpress | 2009-01-20
SECONDARY ACCESSION(S): GSE13046PRJNA109957
REPOSITORIES: GEO, ArrayExpress
Larrea Esther E Aldabe Rafael R Gonzalez Iranzu I Segura Victor V Sarobe Pablo P Echeverria Itziar I Prieto Jesus J
Journal of virology 20090121 7
Oncostatin M (OSM) is released together with type I interferon (IFN) by activated dendritic cells, suggesting a concerted action of these cytokines in the biological response against infection. We found that OSM increases the antiviral effect of IFN-alpha in Huh7 hepatoma cells infected with hepatitis A or hepatitis C virus and synergizes with IFN-alpha in the induction of antiviral genes. The combination of OSM and IFN-alpha led to upregulation of both STAT1 and STAT3 together with intense and ...[more]