Dataset Information


Transcriptional profiling of Escherichia coli

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE12877: Transcriptional profiling of Escherichia coli after addition of CO-RMs to aerobically growing cells GSE12878: Transcriptional profiling of Escherichia coli after addition of CO-RMs to anaerobically growing cells Refer to individual Series

ORGANISM(S): Escherichia coli  

SUBMITTER: Robert Poole 

PROVIDER: E-GEOD-13048 | ArrayExpress | 2010-06-24



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Carbon monoxide-releasing antibacterial molecules target respiration and global transcriptional regulators.

Davidge Kelly S KS   Sanguinetti Guido G   Yee Chu Hoi CH   Cox Alan G AG   McLeod Cameron W CW   Monk Claire E CE   Mann Brian E BE   Motterlini Roberto R   Poole Robert K RK  

The Journal of biological chemistry 20081217 7

Carbon monoxide, a classical respiratory inhibitor, also exerts vasodilatory, anti-inflammatory, and antiapoptotic effects. CO-releasing molecules have therapeutic value, increasing phagocytosis and reducing sepsis-induced lethality. Here we identify for the first time the bacterial targets of Ru(CO)(3)Cl(glycinate) (CORM-3), a ruthenium-based carbonyl that liberates CO rapidly under physiological conditions. Contrary to the expectation that CO would be preferentially inhibitory at low oxygen te  ...[more]

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