Transcriptomics

Dataset Information

5

Immunohistochemical and Clinical Characterization of the Basal-like Subtype


ABSTRACT: 3 fresh frozen Breast tumor from the University of North Carolina at Chapel Hill (UNC) were obtained from the UNC Tissue Procurement Facility under an IRB approved protocol. Each experimental sample was ssayed versus a common reference sample that was a modified version of the Stratagene Human Universal Reference (which was further augmented with a 1/10 amount of MCF7 mRNA and 1/10 amount of ME16C mRNA) Keywords = Agilent microarray Keywords = EGFR Keywords = keratin Keywords: parallel sample

ORGANISM(S): Homo sapiens  

SUBMITTER: Charles Perou   Forrest D Hsu  Lars A Akslen  Charles M Perou  Dave Cowan  Matt Van de Rijn  Allen M Gown  Chad Livasy  Lynn Dressler  Gamze Karaca  Tina Hernandez-Boussard  Zhiyuan Hu  Kristin Jensen  Joseph Ragaz  Torsten O Nielsen  Maggie Cheang  C. Blake Gilks 

PROVIDER: E-GEOD-1319 | ArrayExpress | 2010-06-05

SECONDARY ACCESSION(S): GSE1319PRJNA89891

REPOSITORIES: GEO, ArrayExpress

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Publications

Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma.

Nielsen Torsten O TO   Hsu Forrest D FD   Jensen Kristin K   Cheang Maggie M   Karaca Gamze G   Hu Zhiyuan Z   Hernandez-Boussard Tina T   Livasy Chad C   Cowan Dave D   Dressler Lynn L   Akslen Lars A LA   Ragaz Joseph J   Gown Allen M AM   Gilks C Blake CB   van de Rijn Matt M   Perou Charles M CM  

Clinical cancer research : an official journal of the American Association for Cancer Research 20040801 16


PURPOSE: Expression profiling studies classified breast carcinomas into estrogen receptor (ER)+/luminal, normal breast-like, HER2 overexpressing, and basal-like groups, with the latter two associated with poor outcomes. Currently, there exist clinical assays that identify ER+/luminal and HER2-overexpressing tumors, and we sought to develop a clinical assay for breast basal-like tumors. EXPERIMENTAL DESIGN: To identify an immunohistochemical profile for breast basal-like tumors, we collected a se  ...[more]

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