Dataset Information


Sirt6 study

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE13206: Human shSIRT6 TNF-alpha timecourse GSE13207: Mouse Sirt6-/- TNF-alpha timecourse GSE13208: Mouse Sirt6-/- tissues GSE13209: Mouse Sirt6-/- RelA+/- tissues Refer to individual Series

ORGANISM(S): Musculus  

SUBMITTER: Adam S Adler  

PROVIDER: E-GEOD-13272 | ArrayExpress | 2010-06-24



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SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

Kawahara Tiara L A TL   Michishita Eriko E   Adler Adam S AS   Damian Mara M   Berber Elisabeth E   Lin Meihong M   McCord Ron A RA   Ongaigui Kristine C L KC   Boxer Lisa D LD   Chang Howard Y HY   Chua Katrin F KF  

Cell 20090101 1

Members of the sirtuin (SIRT) family of NAD-dependent deacetylases promote longevity in multiple organisms. Deficiency of mammalian SIRT6 leads to shortened life span and an aging-like phenotype in mice, but the underlying molecular mechanisms are unclear. Here we show that SIRT6 functions at chromatin to attenuate NF-kappaB signaling. SIRT6 interacts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB target gene promoters. In SIRT6-deficient cells, hyperace  ...[more]

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