Transcriptomics

Dataset Information

60

Sirt6 study


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE13206: Human shSIRT6 TNF-alpha timecourse GSE13207: Mouse Sirt6-/- TNF-alpha timecourse GSE13208: Mouse Sirt6-/- tissues GSE13209: Mouse Sirt6-/- RelA+/- tissues Refer to individual Series

ORGANISM(S): Musculus  

SUBMITTER: Adam S Adler   

PROVIDER: E-GEOD-13272 | ArrayExpress | 2014-05-04

SECONDARY ACCESSION(S): GSE13272PRJNA109587

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

Kawahara Tiara L A TL   Michishita Eriko E   Adler Adam S AS   Damian Mara M   Berber Elisabeth E   Lin Meihong M   McCord Ron A RA   Ongaigui Kristine C L KC   Boxer Lisa D LD   Chang Howard Y HY   Chua Katrin F KF  

Cell 20090101 1


Members of the sirtuin (SIRT) family of NAD-dependent deacetylases promote longevity in multiple organisms. Deficiency of mammalian SIRT6 leads to shortened life span and an aging-like phenotype in mice, but the underlying molecular mechanisms are unclear. Here we show that SIRT6 functions at chromatin to attenuate NF-kappaB signaling. SIRT6 interacts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB target gene promoters. In SIRT6-deficient cells, hyperace  ...[more]

Similar Datasets

2014-05-01 | E-GEOD-15297 | ArrayExpress
2014-05-01 | E-GEOD-15213 | ArrayExpress
2014-12-10 | E-GEOD-16252 | ArrayExpress
2014-12-10 | E-GEOD-16251 | ArrayExpress
2014-05-02 | E-GEOD-9046 | ArrayExpress
2014-05-02 | E-GEOD-8770 | ArrayExpress
2014-05-02 | E-GEOD-8773 | ArrayExpress
2014-05-02 | E-GEOD-6797 | ArrayExpress
2014-05-02 | E-GEOD-9821 | ArrayExpress
2014-05-01 | E-GEOD-11847 | ArrayExpress