Dataset Information


Effect of p53 on iPS cell generation

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE13312: Role of p53 in mouse iPS cell generation GSE13334: Effect of p53 in human iPS cell generation Refer to individual Series

ORGANISM(S): Musculus  

SUBMITTER: Shinya Yamanaka  

PROVIDER: E-GEOD-13365 | ArrayExpress | 2009-02-28



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Suppression of induced pluripotent stem cell generation by the p53-p21 pathway.

Hong Hyenjong H   Takahashi Kazutoshi K   Ichisaka Tomoko T   Aoi Takashi T   Kanagawa Osami O   Nakagawa Masato M   Okita Keisuke K   Yamanaka Shinya S  

Nature 20090809 7259

Induced pluripotent stem (iPS) cells can be generated from somatic cells by the introduction of Oct3/4 (also known as Pou5f1), Sox2, Klf4 and c-Myc, in mouse and in human. The efficiency of this process, however, is low. Pluripotency can be induced without c-Myc, but with even lower efficiency. A p53 (also known as TP53 in humans and Trp53 in mice) short-interfering RNA (siRNA) was recently shown to promote human iPS cell generation, but the specificity and mechanisms remain to be determined. He  ...[more]

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