Dataset Information


Li-treatment-induced NDI (Li-NDI) in rats

ABSTRACT: 5 rats were offered food containing 40mM Li/Kg dry weight for 4 weeks, and 5 control rats obtained standard food. The RNA from the inner medulla of the Li-treated rats was labeled red (channel 1), and from the control rats labeled green (channel 2). The samples from Li-treated rats 1+2 and control rats 1+2 were hybridized to array Li-NDI 1. The samples from Li-treated rats 3+4 and control rats 3+4 were hybridized to array Li-NDI 2. The samples from Li-treated rat 5 and control rat 5 were hybridized to array Li-NDI 3.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Jørgen Frøkiær   Aleksandra Rojek  Hong Gong  Aleksandra M Rojek  Søren Nielsen  Jakob Nielsen  Young-Hee Kim  Tae-Hwan Kwon 

PROVIDER: E-GEOD-1341 | ArrayExpress | 2004-09-01



altmetric image


Altered expression of selected genes in kidney of rats with lithium-induced NDI.

Rojek Aleksandra A   Nielsen Jakob J   Brooks Heddwen L HL   Gong Hong H   Kim Young-Hee YH   Kwon Tae-Hwan TH   Frøkiaer Jørgen J   Nielsen Søren S  

American journal of physiology. Renal physiology 20050201 6

Lithium treatment is associated with development of nephrogenic diabetes insipidus, caused in part by downregulation of collecting duct aquaporin-2 (AQP2) and AQP3 expression. In the present study, we carried out cDNA microarray screening of gene expression in the inner medulla (IM) of lithium-treated and control rats, and selected genes were then investigated at the protein level by immunoblotting and/or immunohistochemistry. The following genes exhibited significantly altered transcription and  ...[more]

Similar Datasets

2010-06-09 | E-GEOD-686 | ArrayExpress
2010-05-08 | E-GEOD-15948 | ArrayExpress
2002-02-11 | E-GEOD-23 | ArrayExpress
2002-02-11 | E-GEOD-20 | ArrayExpress
2010-06-10 | E-GEOD-1706 | ArrayExpress
2010-06-05 | E-GEOD-1319 | ArrayExpress
2007-09-13 | E-GEOD-5874 | ArrayExpress
2009-12-02 | E-GEOD-11027 | ArrayExpress
2009-12-02 | E-GEOD-11030 | ArrayExpress
2009-12-02 | E-GEOD-11028 | ArrayExpress