Transcriptomics

Dataset Information

3

Li-treatment-induced NDI (Li-NDI) in rats


ABSTRACT: 5 rats were offered food containing 40mM Li/Kg dry weight for 4 weeks, and 5 control rats obtained standard food. The RNA from the inner medulla of the Li-treated rats was labeled red (channel 1), and from the control rats labeled green (channel 2). The samples from Li-treated rats 1+2 and control rats 1+2 were hybridized to array Li-NDI 1. The samples from Li-treated rats 3+4 and control rats 3+4 were hybridized to array Li-NDI 2. The samples from Li-treated rat 5 and control rat 5 were hybridized to array Li-NDI 3.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Jørgen Frøkiær   Aleksandra Rojek  Hong Gong  Aleksandra M Rojek  Søren Nielsen  Jakob Nielsen  Young-Hee Kim  Tae-Hwan Kwon 

PROVIDER: E-GEOD-1341 | ArrayExpress | 2004-09-01

SECONDARY ACCESSION(S): GSE1341PRJNA90029

REPOSITORIES: GEO, ArrayExpress

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Publications

Altered expression of selected genes in kidney of rats with lithium-induced NDI.

Rojek Aleksandra A   Nielsen Jakob J   Brooks Heddwen L HL   Gong Hong H   Kim Young-Hee YH   Kwon Tae-Hwan TH   Frøkiaer Jørgen J   Nielsen Søren S  

American journal of physiology. Renal physiology 20050201 6


Lithium treatment is associated with development of nephrogenic diabetes insipidus, caused in part by downregulation of collecting duct aquaporin-2 (AQP2) and AQP3 expression. In the present study, we carried out cDNA microarray screening of gene expression in the inner medulla (IM) of lithium-treated and control rats, and selected genes were then investigated at the protein level by immunoblotting and/or immunohistochemistry. The following genes exhibited significantly altered transcription and  ...[more]

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