Dataset Information


Mechanism and transcriptional program of YB-1 in breast cancer cell lines.

ABSTRACT: YB-1 controls epithelial-mesenchymal transitions by restricting translation of growth-related mRNAs and enabling expression of EMT-inducing transcription factors. We used microarrays to characterize the direct transcriptional and indirect translational regulation of mRNAs by exogenous YB-1 in breast cancer cell lines. Keywords: gene expression profiling To evaluate this in a genome-wide manner we compared microarray expression profiles of total mRNA and mRNAs isolated from Ps (translationally active) or post-Ps (translationally inactive) fractions of MCF10AT-MSCV vs. MCF10AT-YB-1 cells

ORGANISM(S): Homo sapiens  

SUBMITTER: Valentina Evdokimova   Elai Davicioni  Poul Sorensen 

PROVIDER: E-GEOD-13410 | ArrayExpress | 2008-10-30



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Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition.

Evdokimova Valentina V   Tognon Cristina C   Ng Tony T   Ruzanov Peter P   Melnyk Natalya N   Fink Dieter D   Sorokin Alexey A   Ovchinnikov Lev P LP   Davicioni Elai E   Triche Timothy J TJ   Sorensen Poul H B PH  

Cancer cell 20090501 5

Increased expression of the transcription/translation regulatory protein Y-box binding protein-1 (YB-1) is associated with cancer aggressiveness, particularly in breast carcinoma. Here we establish that YB-1 levels are elevated in invasive breast cancer cells and correlate with reduced expression of E-cadherin and poor patient survival. Enforced expression of YB-1 in noninvasive breast epithelial cells induced an epithelial-mesenchymal transition (EMT) accompanied by enhanced metastatic potentia  ...[more]

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