Transcriptomics

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Gene expression analysis of Ox40-cre/ROSA-YFP CD4+ T cell subsets


ABSTRACT: An Ox40-cre allele was used for lineage marking of CD4 T cells. Naive T cells that had previously expressed OX40 demonstrated a partially activated phenotype that was distinct from that of the majority of naive T cells. These results are consistent with a minor subpopulation of naive T cells being dependent on strong signaling responses to thymic self ligands. Keywords: T cell population comparison. Characterization of a novel subpopulation of naive T cells. Four types of T cells were sorted from mice (naive, CD44lo, CD44hi and Treg).

ORGANISM(S): Mus musculus  

SUBMITTER: Nigel Killeen   Mark Klinger 

PROVIDER: E-GEOD-13502 | ArrayExpress | 2010-04-03

SECONDARY ACCESSION(S): GSE13502PRJNA110101

REPOSITORIES: GEO, ArrayExpress

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Publications

Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands.

Klinger Mark M   Kim Joong Kyu JK   Chmura Stephen A SA   Barczak Andrea A   Erle David J DJ   Killeen Nigel N  

Journal of immunology (Baltimore, Md. : 1950) 20090401 8


OX40 is a member of the TNF receptor family expressed on activated and regulatory T (Treg) cells. Using an Ox40-cre allele for lineage marking, we found that a subpopulation of naive T cells had also previously expressed OX40 in the thymus. Ox40-cre was induced in a small fraction of thymocytes that were OX40(+), some of which were CD25(high) Treg cell precursors. Thymic OX40 expression distinguished cells experiencing a strong signaling response to positive selection. Naive T cells that had pre  ...[more]

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