Transcriptomics

Dataset Information

35

Transcription profiling of human biopsies from subcutaneous adipose tissue from unrelated individuals reveals galanin preproprotein is associated with elevated plasma triglycerides


ABSTRACT: Assessment of mRNA expression levels in fat biopsies from subcutaneous adipose tissue from unrelated individuals. Experiment Overall Design: Subcutaneous adipose tissue from 49 unrelated individuals.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Christopher L. Plaisier   

PROVIDER: E-GEOD-13506 | ArrayExpress | 2012-03-27

SECONDARY ACCESSION(S): GSE13506PRJNA110109

REPOSITORIES: GEO, ArrayExpress

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Publications


There is increasing physiological evidence in rodents connecting the neuropeptide galanin to triglyceride (TG) levels. We hypothesized that variation in the galanin preproprotein (GAL) gene may contribute to hypertriglyceridemia (HTG) in humans.We investigated GAL as a TG candidate gene by genotyping 4 tagSNPs in Dutch, Finnish, and Mexican familial combined hyperlipidemia (FCHL) families as well as in white combined hyperlipidemia cases/controls (n=2471). The common allele of rs2187331, residin  ...[more]

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