Transcriptomics

Dataset Information

31

Transcription profiling of mouse liver and brown adipose tissue from KRAP deficient mice


ABSTRACT: KRAP (Ki-ras-induced actin-interacting protein) is a cytoskeleton-associated protein and a ubiquitous protein among tissues, originally identified as a cancer-related molecule. KRAP-deficient (KRAP-/-) mice show enhanced metabolic rate, decreased adiposity, improved glucose tolerance, hypoinsulinemia and hypoleptinemia. KRAP-/- mice are also protected against high-fat diet-induced obesity and insulin resistance despite of hyperphagia. This SuperSeries is composed of the following subset Series:; GSE13582: Expression data from BAT of the KRAP deficient mice; GSE13583: Expression data from liver of the KRAP deficient mice Experiment Overall Design: Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: takahiro fujimoto   

PROVIDER: E-GEOD-13585 | ArrayExpress| 2012-03-27

SECONDARY ACCESSION(S): GSE13585PRJNA110689

REPOSITORIES: GEO, ArrayExpress

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Publications

Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice.

Fujimoto Takahiro T   Miyasaka Kyoko K   Koyanagi Midori M   Tsunoda Toshiyuki T   Baba Iwai I   Doi Keiko K   Ohta Minoru M   Kato Norihiro N   Sasazuki Takehiko T   Shirasawa Senji S  

PloS one 20090121 1


Obesity and related metabolic disorders have become leading causes of adult morbidity and mortality. KRAP (Ki-ras-induced actin-interacting protein) is a cytoskeleton-associated protein and a ubiquitous protein among tissues, originally identified as a cancer-related molecule, however, its physiological roles remain unknown. Here we demonstrate that KRAP-deficient (KRAP(-/-)) mice show enhanced metabolic rate, decreased adiposity, improved glucose tolerance, hypoinsulinemia and hypoleptinemia. K  ...[more]

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