Ontology highlight
ABSTRACT:
INSTRUMENT(S): 418 [Affymetrix]
ORGANISM(S): Homo sapiens
SUBMITTER: Wenbin Wei
PROVIDER: E-GEOD-13597 | ArrayExpress | 2009-11-10
SECONDARY ACCESSION(S): GSE13597PRJNA110661
REPOSITORIES: GEO, ArrayExpress
Bose Shikha S Yap Lee-Fah LF Fung Matthew M Starzcynski Jane J Saleh Amyza A Morgan Susan S Dawson Christopher C Chukwuma Marilyn B MB Maina Esther E Buettner Maike M Wei Wenbin W Arrand John J Lim Paul V H PV Young Lawrence S LS Teo Soo Hwang SH Stankovic Tatjana T Woodman Ciaran B J CB Murray Paul G PG
The Journal of pathology 20090201 3
A micro-array analysis using biopsies from patients with EBV-positive undifferentiated nasopharyngeal carcinoma (NPC) and from cancer-free controls revealed down-regulation of tumour suppressor genes (TSG) not previously associated with this disease; one such gene was the ataxia telangiectasia mutated (ATM) gene. Q-PCR confirmed down-regulation of ATM mRNA and ATM protein expression in tumour cells was weak or absent in almost all cases. In NPC cell lines, however, ATM was down-regulated only in ...[more]