Transcriptomics

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Transcription profiling of mouse lung from T1 alpha (-/-) vs. wild type at fetal and term developmental stages


ABSTRACT: We compared gene expression in T1alpha (-/-) lungs vs wild type at dpc 18.5 when the phenotype is moderate and at term when the phenotype is more severe. Lungs present narrow and irregular alveolar spaces, thicker mesenchyme, reduced number of attenuated type I cells, normal numbers of type II cells and secreted surfactant. At term, but not a dpc 18.5, there is increased proliferation of distal cells. We compared gene expression of T1alpha null mutant lungs to wild type lungs at dpc 18.5. The mutant phenotype at this developmental stage is moderate but the alveolar sacs are narrower than normal.

ORGANISM(S): Mus musculus  

SUBMITTER: Maria Isabel Ramirez   

PROVIDER: E-GEOD-1363 | ArrayExpress | 2007-11-22

SECONDARY ACCESSION(S): GDS782GSE1363PRJNA90117

REPOSITORIES: GEO, ArrayExpress

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Publications

Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development.

Millien Guetchyn G   Spira Avrum A   Hinds Anne A   Wang Junling J   Williams Mary C MC   Ramirez Maria I MI  

BMC developmental biology 20060725


Development of lung alveolar sacs of normal structure and size at late gestation is necessary for the gas exchange process that sustains respiration at birth. Mice lacking the lung differentiation gene T1alpha [T1alpha(-/-)] fail to form expanded alveolar sacs, resulting in respiratory failure at birth. Since little is known about the molecular pathways driving alveolar sacculation, we used expression microarrays to identify genes altered in the abnormal lungs and, by inference, may play roles i  ...[more]

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