Transcriptomics

Dataset Information

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Total-body irradiation dose response


ABSTRACT: Duplicate hybridizations with fluorochrome switching were performed following the first two fractions of total body irradiation for accumulated doses of 1.5 Gy and 3.0 Gy. Control samples for all hybridizations were from the same patient before the beginning of treatment.

ORGANISM(S): Homo sapiens  

SUBMITTER: Andrew Yeager   Marcy B Grace  Christopher B McLeland  Sally A Amundson  Joel S Greenberger  Albert J Fornace  Qimin Zhan  Michael W Epperly  Sally Amundson 

PROVIDER: E-GEOD-1366 | ArrayExpress | 2010-06-09

SECONDARY ACCESSION(S): GSE1366PRJNA90123

REPOSITORIES: GEO, ArrayExpress

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Publications

Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients.

Amundson Sally A SA   Grace Marcy B MB   McLeland Christopher B CB   Epperly Michael W MW   Yeager Andrew A   Zhan Qimin Q   Greenberger Joel S JS   Fornace Albert J AJ  

Cancer research 20040901 18


After initially identifying potential biomarkers of radiation exposure through microarray studies of ex vivo irradiated human peripheral white blood cells, we have now measured the in vivo responses of several of these biomarker genes in patients undergoing total body irradiation. Microarray analysis has identified additional in vivo radiation-responsive genes, although the general in vivo patterns of stress-gene induction appear similar to those obtained from ex vivo white blood cell experiment  ...[more]

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