Transcriptomics

Dataset Information

6

MicroRNA-101 represses EZH2 in cancer


ABSTRACT: To determine the phenotypic overlap between restoring miR-101 expression in bladder cancer cells and knocking down EZH2. Either control precursors, pre-miR-101, control siRNA, or EZH2 siRNA were transfected in triplicate into UM-UC-3 cells for 72 hours at a final concentration of 50 nM.

ORGANISM(S): Homo sapiens  

SUBMITTER: Jeffrey M Friedman   Jeffrey Friedman 

PROVIDER: E-GEOD-13674 | ArrayExpress | 2010-06-25

SECONDARY ACCESSION(S): GSE13674PRJNA110419

REPOSITORIES: GEO, ArrayExpress

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Publications

The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.

Friedman Jeffrey M JM   Liang Gangning G   Liu Chun-Chi CC   Wolff Erika M EM   Tsai Yvonne C YC   Ye Wei W   Zhou Xianghong X   Jones Peter A PA  

Cancer research 20090303 6


The Polycomb Repressive Complex 2 (PRC2) mediates epigenetic gene silencing by trimethylating histone H3 lysine 27 (H3K27me3) and is known to aberrantly silence tumor suppressor genes in cancer. EZH2, the catalytic subunit of PRC2, enhances tumorigenesis and is commonly overexpressed in several types of cancer. Our microRNA profiling of bladder transitional cell carcinoma (TCC) patient samples revealed that microRNA-101 (miR-101) is down-regulated in TCC, and we showed that miR-101 inhibits cell  ...[more]

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