Transcriptomics

Dataset Information

40

Transcription profiling of human MLL-AF10 myeloid leukemia cellular subsets


ABSTRACT: Leukemia cells from mice with MLL-AF10 AML were fractionated into separate sub-populations on the basis of c-kit expression, which correlates with MLL LSC frequency (Somervaille and Cleary, 2006). The sorted AML sub-populations exhibited substantial differences in their frequencies of AML CFCs/LSCs (mean 14-fold) and morphologic features, consistent with a leukemia cell hierarchy with maturation through to terminally differentiated neutrophils. Experiment Overall Design: Leukemic splenocytes from four mice with MLL-AF10 AML were sub-fractionated in to c-kit high and c-kit negative sub-populations by FACS.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: Tim C. Somervaille   

PROVIDER: E-GEOD-13692 | ArrayExpress | 2011-06-10

SECONDARY ACCESSION(S): GSE13692PRJNA114579

REPOSITORIES: GEO, ArrayExpress

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