Dataset Information

Persistent Organic Pollutants cause insulin resistance and ruin the health effects of salmon oil

ABSTRACT: Transcriptional profiling of Rat liver submitted to high fat diets made with either crude (HFC) or refined salmon oil (HFR). Keywords: transcriptomic analysis Two groups of rats were submitted to high fat diet containing either crude salmon oil (HFC) or refined salmon oil (HFR). After 28 days, livers were retrieved and RNA extracted. A pool of RNA from HFR group was used as the reference group. Each HFC was compared to reference group (pool of HFR). Five biological replicates were processed.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Hubert Vidal Jerome Ruzzin emmanuelle meugnier Emmanuelle Meugnier Sandra Pesenti

PROVIDER: E-GEOD-13716 | ArrayExpress | 2010-05-19

SECONDARY ACCESSION(S): GSE13716PRJNA110393

REPOSITORIES: GEO, ArrayExpress

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Publications

Persistent organic pollutant exposure leads to insulin resistance syndrome.

Ruzzin Jérôme J Petersen Rasmus R Meugnier Emmanuelle E Madsen Lise L Lock Erik-Jan EJ Lillefosse Haldis H Ma Tao T Pesenti Sandra S Sonne Si Brask SB Marstrand Troels Torben TT Malde Marian Kjellevold MK Du Zhen-Yu ZY Chavey Carine C Fajas Lluis L Lundebye Anne-Katrine AK Brand Christian Lehn CL Vidal Hubert H Kristiansen Karsten K Frøyland Livar L

Environmental health perspectives 20091119 4

BACKGROUND: The incidence of the insulin resistance syndrome has increased at an alarming rate worldwide, creating a serious challenge to public health care in the 21st century. Recently, epidemiological studies have associated the prevalence of type 2 diabetes with elevated body burdens of persistent organic pollutants (POPs). However, experimental evidence demonstrating a causal link between POPs and the development of insulin resistance is lacking. OBJECTIVE: We investigated whether exposure ...[more]

PMID: 20064776

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