Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: James L Ferrara Elizabeth Hexner Peter Klein Yi Zhang Jiu Jiang Shin Mineishi Shuaiyang Cui Jian Huang Jina Wang Elizabeth Bacon Rork Kuick Koji Kato Stephan G Emerson Pavan Reddy
PROVIDER: E-GEOD-13743 | ArrayExpress | 2010-06-08
SECONDARY ACCESSION(S): GSE13743PRJNA109393
REPOSITORIES: GEO, ArrayExpress
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20100129 6
A hallmark of graft-versus-host-disease (GVHD), a life-threatening complication after allogeneic hematopoietic stem cell transplantation, is the cytopathic injury of host tissues mediated by persistent alloreactive effector T cells (T(E)). However, the mechanisms that regulate the persistence of alloreactive T(E) during GVHD remain largely unknown. Using mouse GVHD models, we demonstrate that alloreactive CD8(+) T(E) rapidly diminished in vivo when adoptively transferred into irradiated secondar ...[more]