Dataset Information


Profiling of hypothalamus tissue from the F2 M16xICR mouse cross.

ABSTRACT: We profiled gene expression in hypothalamus tissue from F2 progeny from a cross between the outbred M16 (selectively bred for rapid weight gain) and ICR (control) mouse strains. We developed a framework for reconstructing tissue-to-tissue coexpression networks between genes in hypothalamus, liver or hypothalamus tissues that are independent of networks constructed from single tissue analyses. The subnetworks we identify as specific to tissue-to-tissue interactions associate with multiple obesity-relevant biological functions like circadian rhythm, energy balance, stress response, or immune response. Keywords: Tissue profiling in a mouse F2 cross. We analyzed 308 hypothalamus samples.

ORGANISM(S): Mus musculus  

SUBMITTER: Mark F Allan   Eric E Schadt  Carmen Argman  Daniel Pomp  Radu Dobrin  Mark E Parrish  Jun Zhu  Cliona Molony  Sonia Carlson 

PROVIDER: E-GEOD-13745 | ArrayExpress | 2010-06-22



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Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease.

Dobrin Radu R   Zhu Jun J   Molony Cliona C   Argman Carmen C   Parrish Mark L ML   Carlson Sonia S   Allan Mark F MF   Pomp Daniel D   Schadt Eric E EE  

Genome biology 20090522 5

<h4>Background</h4>Obesity is a particularly complex disease that at least partially involves genetic and environmental perturbations to gene-networks connecting the hypothalamus and several metabolic tissues, resulting in an energy imbalance at the systems level.<h4>Results</h4>To provide an inter-tissue view of obesity with respect to molecular states that are associated with physiological states, we developed a framework for constructing tissue-to-tissue coexpression networks between genes in  ...[more]

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