Transcriptomics

Dataset Information

3

Comparison between caruncles and intercaruncles in AI, IVF-ET and SCNT pregnancies


ABSTRACT: Implantation is crucial for placental development whose quality will directly impact fetal growth and pregnancy success with possible consequences on post-natal health. We postulated that early perturbations of the conceptus-maternal environment communication may alter the endometrium physiology that could account for the final reproductive outcome. Using cattle as an animal model, we compared gene expression profiles of the endometrial caruncular and intercaruncular areas at implantation in three types of pregnancies, namely artificial insemination (AI), in vitro fertilization with embryo transfer (IVF-ET) or somatic cell nuclear transfer (SCNT). Less than 35% of the differentially regulated genes were found to be common between AI, IVF-ET, and SCNT conditions. Compared to AI, numerous biological functions and several canonical pathways and genes were found to be significantly affected in IVF-ET or SCNT, with a major impact on metabolism and immune function in SCNT. Our data show that endometrium can fine-tune its physiology and could be considered as a biological sensor in response to pregnancy manipulations. Determining the limits of the endometrial plasticity should bring new insights on the contribution of the maternal compartment to the issue of pregnancy. Keywords: Fluorescence Microarray 30 samples

ORGANISM(S): Bos taurus  

SUBMITTER: Séverine Degrelle   XCindy Tian  Robin E Evert  Yvan Heyman  Corinne Giraud-Delville  Laurent Galio  Julie Aubert  Harris A Lewin  Isabelle Hue  Nadéra Mansouri-Attia  Xiangzhong Yang  Jean-Paul Renard  Olivier Sandra 

PROVIDER: E-GEOD-14047 | ArrayExpress | 2010-06-20

SECONDARY ACCESSION(S): GSE14047PRJNA114519

REPOSITORIES: GEO, ArrayExpress

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Publications

Endometrium as an early sensor of in vitro embryo manipulation technologies.

Mansouri-Attia Nadéra N   Sandra Olivier O   Aubert Julie J   Degrelle Séverine S   Everts Robin E RE   Giraud-Delville Corinne C   Heyman Yvan Y   Galio Laurent L   Hue Isabelle I   Yang Xiangzhong X   Tian X Cindy XC   Lewin Harris A HA   Renard Jean-Paul JP  

Proceedings of the National Academy of Sciences of the United States of America 20090318 14


Implantation is crucial for placental development that will subsequently impact fetal growth and pregnancy success with consequences on postnatal health. We postulated that the pattern of genes expressed by the endometrium when the embryo becomes attached to the mother uterus could account for the final outcome of a pregnancy. As a model, we used the bovine species where the embryo becomes progressively and permanently attached to the endometrium from day 20 of gestation onwards. At that stage,  ...[more]

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