Transcriptomics

Dataset Information

7

Expression signatures and cytogenetic aberrations in HPV16 E6, E7 and E6/E7-positive immortalized human epithelial cells


ABSTRACT: Identification of genetic/cytogenetic alterations and differentially expressed cellular genes in HPV16 E6, E7 and E6/E7 positive human foreskin keratinocytes Keywords: ordered We used microarrays to identify differentially expressed genes in human foreskin keratinocytes (HFK) transfected with retroviral vectors harboring the human papillomavirus type 16 oncogenes E6, E7, or E6/E7 in comparison to HFK containing the empty vector control pLXSN.

ORGANISM(S): Homo sapiens  

SUBMITTER: Ludger Klein-Hitpass   Kerstin Kleine-Lowinski  Antje Repenning 

PROVIDER: E-GEOD-14051 | ArrayExpress | 2013-11-27

SECONDARY ACCESSION(S): GSE14051PRJNA112413

REPOSITORIES: GEO, ArrayExpress

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Publications

Complementation of non-tumorigenicity of HPV18-positive cervical carcinoma cells involves differential mRNA expression of cellular genes including potential tumor suppressor genes on chromosome 11q13.

Kehrmann Angela A   Truong Ha H   Repenning Antje A   Boger Regina R   Klein-Hitpass Ludger L   Pascheberg Ulrich U   Beckmann Alf A   Opalka Bertram B   Kleine-Lowinski Kerstin K  

Cancer genetics 20130701 7-8


The fusion between human tumorigenic cells and normal human diploid fibroblasts results in non-tumorigenic hybrid cells, suggesting a dominant role for tumor suppressor genes in the generated hybrid cells. After long-term cultivation in vitro, tumorigenic segregants may arise. The loss of tumor suppressor genes on chromosome 11q13 has been postulated to be involved in the induction of the tumorigenic phenotype of human papillomavirus (HPV)18-positive cervical carcinoma cells and their derived tu  ...[more]

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