Transcriptomics

Dataset Information

3

Gene category-specific regulation of transcription elongation across the yeast genome


ABSTRACT: Analysis of genome-wide differences of transcription using Genomic run-on (GRO), RNApol II ChIP-on-Chip, cDNA analysis and ChIP-on-Chip. This SuperSeries is composed of the following subset Series: GSE14060 RNA pol II ChIP on chip (RPCC) GSE14077 RPCC analysis of rap1-sil, tpk1 & tpk2 GSE14080 GRO analysis of rap1-sil, tpk1 & tpk2 GSE14082 Analysis of Spt16 depletion GSE1002 YPD to YPGal timecourse Refer to individual Series

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Silvia Jimeno-Gonzalez   Sebastian Chavez  Alfonso Rodriguez-Gil  Vicent Pelechano  Jose Garcia-Martinez  Jose E Perez-Ortin  Jose E. Perez-Ortin 

PROVIDER: E-GEOD-14084 | ArrayExpress | 2010-06-24

SECONDARY ACCESSION(S): GSE14084PRJNA112509

REPOSITORIES: GEO, ArrayExpress

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Publications

Regulon-specific control of transcription elongation across the yeast genome.

Pelechano Vicent V   Jimeno-González Silvia S   Rodríguez-Gil Alfonso A   García-Martínez José J   Pérez-Ortín José E JE   Chávez Sebastián S  

PLoS genetics 20090821 8


Transcription elongation by RNA polymerase II was often considered an invariant non-regulated process. However, genome-wide studies have shown that transcriptional pausing during elongation is a frequent phenomenon in tightly-regulated metazoan genes. Using a combination of ChIP-on-chip and genomic run-on approaches, we found that the proportion of transcriptionally active RNA polymerase II (active versus total) present throughout the yeast genome is characteristic of some functional gene classe  ...[more]

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